With the 70s behind him, San Diego's top rated newsman, Ron Burgundy, returns to take New York's first 24-hour news channel by storm.

For their first day on the job as the new protectors of Metro City, Megamind and Minion are selling off the gadgets from their evil lair. But when one seemingly harmless "button" unleashes the gigantic robot MEGA-MEGAmind, the duo will have to resort their old tricks to restore order.

Bumbling supervillain Megamind finally defeats his nemesis, the superhero Metro Man. But without a hero, he loses all purpose and must find new meaning to his life.

Desperate to be the top cops on the force, two misfit detectives break free from their desk jobs and stumble onto the biggest case of their careers.